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Sunday, December 23, 2007

Herbs and Natural Supplements for Breast Cancer

Herbs and Natural Supplements for Breast Cancer
by: Brian B. Carter, MS, LAc

A returning patient called me yesterday. She was a breast cancer survivor when I saw her as a student intern in Chinese medical school. If I had been more confident at the time, I would have suggested she be diligent in preventing a recurrence of breast cancer, and explained how she might attempt that with Chinese medicine.

Even if I had, however, she might not have followed my advice, because Chinese medicine's credibility has yet to catch up with its sophistication, efficacy, and research.

It's well known that acupuncture can help with palliative strategies in cancer- for pain relief, itching relief, and nausea. The topic examined less often is: can Chinese medicine fight cancer directly? Many acupuncture teachers and practitioners warn us not to claim that it can - they suggest there's some law against us treating cancer, and you can see how reactive conservative doctors might be to the idea. They are accustomed to having control of the treatment of all cancer, regardless of whether they can help individual patients, or how much damage their therapies cause. Still, there is research and a clinical track record that suggests Chinese medicine can do more than just reduce discomforts.

I can't resolve all by myself in this short space the political issues and ethical issues of alternative medical treatment. But, I suggest that if a patient who refuses conventional treatment, then their alternative practitioners should find out everything they can and do all they can to help the patient recover, or at least become more comfortable.

Even in my small alternative medicine library, I have 2 books on Chinese herbs for cancer, and a third that summarizes the research on natural compounds used in cancer therapy. On PubMed, I found even more scientific references about herbs and breast cancer specifically. It's not the case that there isn't research on this topic. Instead, as with much Chinese medicine research, the information is either unknown, or unused by Western physicians. What follows is a short summary of the scientific information I found (in less than an hour) on alternative medicine and breast cancer. At the end, I've provided some herbal formulas for practitioners.

Human Studies on Natural Compounds for Cancer Therapy:
John Boik, MacOM, LAc has contributed a weighty work called Natural Compounds in Cancer Therapy (Oregon Medical Press, 2001). It not only reviews hundreds of scientific references, but also explains many specific cancer disease processes. The following human studies are drawn from that book, but their specific references are also included.

Scientific research is done either in vitro (test tube), in animals, or in humans. Knowing that any non-human research is easily discounted by skeptics, I've chosen only the human studies. However, the other studies are also interesting and helpful, so if you want more, get Boik's book. All of the following are specific for breast cancer.

6 Bromelain tablets for 10 days corrected deficient macrophage activity. (1)
Vitamin C was found to not necessarily good for breast cancer and may actually have accelerated some patients' deaths, but those who lived had fewer recurrences. (2,3)
Eleuthrococcus stimulated the immune system in breast cancer patients. (4)
Higher levels of fat intake in breast cancer patients was associated with increased risks of recurrence and death. (5)
In post mastectomy breast cancer patients, there were higher survival rates among those who took enzymes. (6)
Enzyme therapy also improved weight gain, fatigue, depression and quality of life. (6)
A diet of 20% fish oil (24g/kg) improved the anti-tumor effect of the chemotherapy drug mitomycin due to enhanced lipid peroxidation. [This was a combined human/animal study where human cells were studied after transplantation to an animal] (7)
Vitamin D3 helps chemotherapy drugs work better. (8)

Chinese herbs for Breast Cancer

I have access to three sources for Chinese herbs and breast cancer. One is a book called Anticancer Chinese Drugs by Lien & Li, which surveys more than 120 plants used to treat cancer, and examines the chemical structure and effects of individual compounds from those plants. Below are 4 compounds from this book specifically for breast cancer. Unfortunately, none of these are among the 500 or so common Chinese herbs referred to in the standard reference, Materia Medica, by Bensky & Barolet. Note that there are closer to 12,000 substances called herbs used here and there in Chinese medicine.

Labiatae I. longitubis inhibits br ca cells in vitro (Lien/Li, 10).
Maytansine (from maytanus oratus, serrata, buchananii, and hookeri) prevents polymerization of tubulin to microtubules (ibid, 85). (9)
9-hydroxy-2-methyl-ellipticinum (from ochrosia moorei and borbonica) has therapeutic value in advanced breast cancer (ibid, 78). (10)

In phase III clinical trials, VP-16 (from podophyllum berberidaceae) has caused responses in a number of cancers including breast cancer (ibid, 60). (11)

More Science:

A quick search of PubMed for more research on herbs for breast cancer yielded 4 interesting results:

Huang lian (coptis) inhibited tumor growth (gastric, colon, breast)... "These results indicate that traditional Chinese herbs may represent a new source of agents designed for selective inhibition of cyclin dependent kinases in cancer therapy." (12)

Hemsleya amabilis extract significantly inhibited tumor cell growth and colony formation and promoted tumor cell death.(13)

Triptolide (TPL), a diterpenoid triepoxide purified from the Chinese herb Tripterygium wilfordii Hook F, in vitro inhibited the proliferation and colony formation of tumor cells and the antitumor effect of TPL was comparable or superior with that of conventional antitumor drugs, such as Adriamycin, mitomycin, and cisplatin. (14)

Huang qi root specifically inhibits gastric cancer cells growth in vitro - its mechanism is mainly inhibition of cancer cell growth, not attacking or dismantling of existing cancer cells. (15)

Chinese Herbal Formulas for Breast Cancer (For Practitioner Reference)

My final source is a book called Treating Cancer with Chinese Herbs (Hsu, Ohai Press, 1990). This book is mainly for practitioners to learn from and use. It is not scientifically referenced - of course, some Chinese physicians and writers are not familiar with the Western insistence on always quoting your sources, so some of this information may have science behind it. We just can't tell from Hsu's book. But here's a suggestion patients can try at home:

Combine the juice of 90g of fresh asparagus (or 30g peeled) with yellow wine (a traditional Chinese wine made from rice) once a day.

References:

1.Eckert K, Grabowska E, Stange R, et al. Effects of oral bromelain administrations on the impaired immunocytoxicity of mononuclear cells from mammary tumors. Oncol Rep 1999 Nov-Dec; 6(6):1191-9.
2.Poulter JM, White WF, Dickerson JW. Ascorbic acid supplementation and five year survival rates in women with breast cancer. Acta Vitaminol Enzymol 1984; 6(3):175-82.
3.Murata A, Morishige F, Yamaguchi H. Prolongation of survival times of terminal cancer patients by administration of large doses of ascorbate. Int J Vitam Nutr Res Suppl 1982; 23:103-13.
4.Kupin VI, Polevaia EB. [Stimulation of the immunological reactivity of cancer patients by Eleuthrococcus extract.] Vopr Onkol 1986; 32(7):21-6.
5.Saxe GA, Rock CL, Wisha MS, Schottenfield D. Diet and risk for breast cancer recurrence and survival. Breast Cancer Res Treat 1999 Feb; 53(3):241-53.
6.Klaschka F. Oral Enzymes in Oncology: Clinical studies on Wobe-MuGos. MUCOS Pharma GmbH, 1997. http://www.mucos.de
7.Shao Y, Pardini L, Pardini RS. Dietary menhaden oil enhances mitomycin C antitumor activity toward human mammary carcinoma MX-1. Lipids 1995 Nov; 30(11):1035-45.
8.This refers to 7 studies, referenced in shorter style: Ravid A. Cancer Res 1999 Feb 15; 59(4):862-7. Studzinski GP. J Natl Cancer Inst 1986 Apr; 76(4):641-8. Moffatt KA. Clin Cancer Res 1999 Mar; 5(3):695-703. Vink-van Wijngaarden T. Breast Cancer Res Treat 1994 Feb; 29(2):161-8. Saunders DE. Gynecol Oncol 1993 Nov; 51(2):155-9. Cho YL. Cancer Res 1991 Jun 1; 51(11):2848-53. Tanaka H. Clin Orthop 1989 Oct; (247):290-6.
9.There were promising Phase I trials on maytansine against breast cancer in the 1980's, but phase II trials were disappointing.
10.Juret P, Heron JF, Couette JE, Delozier T, Le Talaer JY. Hydroxy-9-methyl-2-ellipticinium for osseous metastases from breast cancer: a 5-year experience. Cancer Treat Rep. 1982 Nov; 66(11): 1909-16.
11.Slayton RE, Blessing JA, Delgado G. Phase II trial of etoposide in the management of advanced or recurrent endometrial carcinoma: a Gynecologic Oncology Group Study. Cancer Treat Rep. 1982 Aug; 66(8): 1669-71. No abstract available.
12.Li XK, Motwani M, Tong W, Bornmann W, Schwartz GK. Huanglian, A chinese herbal extract, inhibits cell growth by suppressing the expression of cyclin B1 and inhibiting CDC2 kinase activity in human cancer cells. Mol Pharmacol. 2000 Dec; 58(6): 1287-93.
13.Wu J, Wu Y, Yang BB. Anticancer activity of Hemsleya amabilis extract. Life Sci. 2002 Sep 20; 71(18): 2161-70.
14.Yang S, Chen J, Guo Z, Xu XM, Wang L, Pei XF, Yang J, Underhill CB, Zhang L. Triptolide inhibits the growth and metastasis of solid tumors. Mol Cancer Ther. 2003 Jan; 2(1): 65-72.
15.Lin J, Dong HF, Oppenheim JJ, Howard OM. Effects of astragali radix on the growth of different cancer cell lines. World J Gastroenterol. 2003 Apr; 9(4): 670-3.

About the Author

Acupuncturist, herbalist, and medical professor Brian B. Carter founded the alternative health megasite The Pulse of Oriental Medicine (http://www.PulseMed.org/). He is the author of the book "Powerful Body, Peaceful Mind: How to Heal Yourself with Foods, Herbs, and Acupressure" (November, 2004). Brian speaks on radio across the country, and has been quoted and interviewed by Real Simple, Glamour, and ESPN magazines.

Tuesday, December 11, 2007

Breast Cancer The Cure

Breast Cancer The Cure
by: Gerald Armstrong


You have my permission to publish this article electronically or in print, free of charge, as long as the bylines are included. A courtesy copy of your publication would be appreciated.

Breast Cancer The Cure

There is no known cure for breast cancer. More than 1.5 million people will be diagnosed with breast cancer this year worldwide. Scientists don't know why most women get breast cancer, yet breast cancer is the most frequent tumor found in women the world over. A woman who dies of breast cancer is robbed of an average of nearly 20 years of her life. Breast cancer knows no social boundaries. It’s a disease that can affect anyone. Some prominent women who’s lives that have been touched by breast cancer include Jill Eikenberry actress age 52; Peggy Fleming age 49 figure skater; Kate Jackson age 50 (Charlies Angels); Olivia Newton-John age 50 actress singer; Nancy Reagan age 77 former first lady; Melissa Etheridge age 43 singer; and the beautiful Suzanne Summers actress. These high rates of breast cancer are not acceptable to the women of the world and must be met with scientific research that provides results.

Despite over a decade of research, and more than $1.7 billion spent, hundereds of women worldwide are dying from breast cancer every day. Yet doctors don’t know how breast cancer starts or how to cure it. Doctors are still approaching treatment for breast cancer in the same old fashioned ways: surgery, radiation, and chemotherapy. Barbarick treatments…And scientists keep doing the same old redundant research that’s simply not working. It doesn’t have to be that way. Gen Cells Cures is a scientific biotechnology company that is focused on a cure for breast cancer. The company is dedicated to curing breast cancer before it’s too late for you. We’re not interested in a cure in five, ten, or twenty years from now. We want your cure for breast cancer within a year or two. We don’t want you to have to under go surgery, radiation, chemotherapy or take toxic drugs.

Why Gen Cells Cures? You can search the medical journals; you can search the internet until your blue in the face. You will find the same old news which is no new news about breast cancer research and treatments. Breast cancer research is locked up in a black whole. Gen Cells Cures is approaching the cure for breast cancer from different angles and using tomorrow’s scientific technologies today. Our expertise is in stem cell research and genomics. Malfunctioning stem cells have already been linked to the development of breast cancer. We’re not talking about using generic stem cells from an egg and sperm cell. There is no genetic match for you with the politically controversial generic stem cells that are always in the news. The isolation of cancer stem cells, coupled with our understanding of genetic mutations causing cancer, and our knowledge of genomics will result in ways to eliminate cancer cells while sparing normal breast tissues.

Genetics and Breast Cancer

People will tell you to accept what you can’t change…Your genetics, your genes, the genes your mother and father handed you when you were born that came with their particular genetic make-up. Most inherited cases of breast cancer have been associated with two genes: BRCA1 and BRCA2. The past five years has been a period of unparalleled discovery in the field of genetics, genomics, and stem cell research, but these discoveries are not being applied to breast cancer treatments. A job that Gen Cells Cures definitely wants to get our hands dirty in. Recently researchers have found that by blocking a gene called beta1-integrin the growth of tumor cells can be stopped. When this gene was removed the tumor cells quit growing. You don’t have to accept the genes that you were given at birth. Gen Cells Cures will be able to manipulate your genes to cure your breast cancer.

Our Cancer Stem Cell and Genomics Program will bring together the top scientific minds in the world under one tin roof to maximize the use of diverse approaches to the understanding of cancer genomics fused with stem cell solutions. Gen Cells Cures isn’t looking for a multi-million dollar biomedical research center like the Stowers Institute in Kansas City, which is a medical center to be admired. A rented tin shack will do just fine. Of course, we would accept hand-me down michroscopes from the Stoweres (billionaires who bought their own multi-million dollar biomedical research center) if they would be gracious enough to grant them to us or we would accept a small prime the pump check to move forward with our research. The Stowerses and all the scientists from the Stowers Institute have an open invitation to visit our lab in the Caribbean. What we are looking for is a cure for breast cancer to stop the humiliation, pain and suffering this menace to society causes millions of women and thousands of men worldwide, and not a new biomedical center… Every dollar invested with us goes into pure medical research and equipment. The same offer goes out to all the millionaires and especially the billionaires of the world. People that come to mind are: Paul Allen, Bill and Melinda Gates, Jon Huntsman, William and Alice Goodman, Ann Lurie, Jamie and Karen Moyer, Harold C. Simmons, Alfred Mann, Sumner M. Redstone, Michael Milton and the Palm beach billionaires, there are simply too many to mention. The combined wealth of the three Microsoft billionaires alone is more than ten times the amount spent by the U.S. Federal Government on research to fight cancer and other deadly diseases. We know we’re in the wrong business to become billionaires ourselves. This kind of biotechnology has never produced even one billionaire. It’s the cure for breast cancer that we want.

Simply put the cancer research organizations are funding the wrong researchers. It’s time to go outside the normal research channels. Do something different. The same story year after year after year and no cure. These unmotivated researchers just aren’t getting results. Let someone else have a shot at it. It’s time to try something new and different. A different approach. There are races for the cure, golf tournaments for the cure, there are walks for the cure, there are foundations for the cure. These foundations have been funding the same ineffective research for more than twenty years now. These foundations have been betting on the wrong horse. Joining the crusade won’t help if the research being done doesn’t take on a twenty-first century scientific approach. It’s been time to move forward scientifically for five years now. But today’s breast cancer researchers are stuck in a twentieth century mind-set. The Excuse is someday we’ll find the cure, but someday doesn’t help today’s victims of breast cancer. We need top notch scientific action today.

The genetics are out of the bottle and stem cell research is moving forward whether the U.S. government likes it or not. Gen Cells Cures has moved off-shore to the Caribbean to avoid the political controversy over stem cell research. I am sure you won’t mind a walk on the beach with me to talk about your cure for your breast cancer. Once we have the cure we can take the cure from the bench to the patient without a long and costly wait for FDA approval. There are many advantages to not having big brother breathing down your neck. The governments of the United States and Western countries have nothing to offer except road blocks, red tape and detours. Our patients don’t have time for political smoke and mirrors. With a little luck we could have your cure before the time comes that you need that dreaded surgery and chemo.

Our gifted world-class researchers are visionary and have been schooled in winning and have courage, creativity, can-do attitudes, burning desires, unfaltering belief and an obsession that they will be there first. By first we mean years ahead of the other biotechnology companies. Like determined, fighting NASCAR drivers our scientists are living to take the chequered flag of biotech and win the coveted race for the cure for breast cancer.

Focused on breakthrough discoveries, Gen Cells Cures nurtures a culture that encourages high standards of excellence, original thinking, hard work and a willingness to take risks. Our world-renowned scientists believe in themselves and its belief that gets us there. The company will seek to develop a work environment that is results focused and team-orientated. We compete against time. Though we compete intensely we maintain high ethical standards and trust and respect for each other. Quality is the cornerstone of all our activities. We seek the highest quality information, decisions and people. Our success depends on superior scientific innovation. We see the scientific method as a multi-step process which includes designing the right experiment, collecting and analyzing data and rational decision making. It is not subjective or emotional but rather a logical, open and rational process.

Our success comes from one simple fact; we are committed to being a science-based, patient-driven company, driven by that one special breast cancer patient…you.

Gen Cells Cures lost most of our one million dollar start-up money in offshore bank scandal and currency devaluation last year. We are now actively pursuing financial support. Unfortunately, the Gen Cells Cures team is made up of great scientific minds and not great marketers, salesmen, or fund raisers. Yes, we are looking for a millionaire or billionaire without a cause to support our work, but if you are not our wealthy saviour, we welcome any help, be it financial or a donation of your time. The scientific team is on stand-by. What we’re lacking is the funding to go forward. We could use motivated salesmen to sell our research, fund raisers, skilled internet marketers or someone just to pass out flyers or mail out promotional material. We could use help from the media with publicity stories, ads and promotions to get the word out. We are particularly interested in looking for assistance from the billionaires of the world; there are approximately 600 in the world. Billionaires like Sergey Brin and Larry Page (Google billionaires), Rupert Murdoch, Ted Turner, and Oprah Winfrey and others who control the media could get our life-saving message to the world fast. We are also hoping that some of my celebrities friends will come forward and spread their wings to help support our breast cancer research: Steven Seagal, Charlie Sheen, Wesley Snipes, Danny Glover, Erik Estrada, Tom Arnold, Dolph Lundgren, Roger Clinton, Bill Clinton, Usher, Hulk Hogan, Ivana Trump, John Secada, Sylvester Stalone, Arnold Schwarzenegger, Mike Reno, Richard Branson, Cindy Crawford, Cher, Demi Moore, Michelle Pfeiffer, and other stars that I have had the good fortune of meeting in person and others celebrities that I hope to meet in the future. (Photos of Gerald and the stars can be viewed at his promotional group listed below.) I am waiting to get my photo with Suzanne Summers!

Gen Cells Cure offers more than hope. We can do the job. If you’re going to eradicate cancer you have to have the right people doing the right research. One thing is for sure. We couldn’t do any worse than what the scientists before us have done. Which is virtually nothing! Help us alleviate the pain and suffering. Together, with your help, we can cure breast cancer.

Article by Gerald Armstrong- scientist0707@yahoo.com
Gerald is the owner of Gen Cells Cures
Visit his group for information about “The Cure” for incurable diseases and aging.
Group address http://www.msnusers.com/cures


About the Author

Hello, Ladies and Gentlemen, I am Gerald Armstrong the owner of Gen Cells Cures a biotech dedicated to finding “The Cure” for incurable diseases and aging. Introducing to the world, the miracle of private, personalized medical research for the individual. I am passionate about molecular biology and what we can do with science to find “The Cure” for those of you suffering from aging and incurable diseases. http://www.msnusers.com/cures

Monday, December 3, 2007

Breast Implant Dangers

Breast Implant Dangers


Breast Implant Dangers 3% suffer leakage within three years causing a deflated implant.
Occasionally, breast implants may break or leak. The saline fill is salt water and will be absorbed by the body without ill effects. Older implants with silicone gel can leak also. If this occurs, one of two things may occur. If breakage of the implant shell that has a contracture scar around it, then it may not feel like anything has happed. If the shell breaks and there is not a contracture scar, then leakage into the surrounding tissue results in a sensation that the implant is deflating. The leaking gel may collect in the breast and a new scar may form around it. In other cases gel can migrate through the lymphatic system to another area of the body. Breaks may require a second operation and replacement of the leaking implant. If the gel has migrated it may not be possible to remove all of the silicone gel. This silicone gel is the what some say is related to the initiation of connective tissue disorders.


For silicone gel and saline-filled implants, some causes of rupture or deflation include : damage by surgical instruments during surgery, overfilling or underfilling of the implant with saline solution (specific only to saline-filled breast implants), capsular contracture ,closed capsulotomy , stresses such as trauma or intense physical manipulation ,excessive compression during mammographic imaging, placement through umbilical incision ,site injury to the breast, normal aging of the implant ,unknown/unexplained reasons.


FDA completed a retrospective study on rupture of silicone gel-filled breast implants. This study was performed in Birmingham, Alabama and included women who had their first breast implant before 1988. Women with silicone gel-filled breast implants had a MRI examination of their breasts to determine the status of their current breast implants. The 344 women who received a MRI examination had a total of 687 implants. Of the 687 implants in the study, at least two of the three study radiologists agreed that 378 implants were ruptured (55%). This means that 69% of the 344 women had at least one ruptured breast implant. Of the 344 women, 73 (21%) had extracapsular silicone gel in one or both breasts. Factors that were associated with rupture included increasing age of the implant, the implant manufacturer, and submuscular rather than subglandular location of the implant.


The most common complication of breast implants is capsular contracture, a tightening of the scar tissue that the body produces around the implant as a natural part of healing. Additional surgery may be required either to remove the scar tissue or to remove—and perhaps replace—the implant. In a prospective clinical study of saline-filled breast implants conducted by Mentor, the cumulative, 3-year, by patient rates of a first occurrence of capsular contracture Grades III and IV were 9% for the 1264 augmentation patients and 30% for the 416 reconstruction patients. In a prospective clinical study of saline-filled breast implants conducted by McGhan, the cumulative, 3-year, by patient rates of a first occurrence of capsular contracture Grades III and IV were 9% for the 901 augmentation patients and 25% for the 237 reconstruction patients.

Saurce: http://www.breastactives.com/?aid=249331